Toxoplasma gondii Infection in Cats
Toxoplasmosis is an infection caused by the Toxoplasma gondii (T. gondii) parasite. It is one of the most common parasitic diseases and is known to affect nearly all warm-blooded animals and humans, but cats are the primary living host.
This parasite completes its life cycle in cats, and they are the only mammals in which this parasite is passed through the feces and into the environment as part of the life cycle. However, contact with raw meat and unwashed produce is also a very significant and well known source of human infection.
Both acute and chronic forms of toxoplasmosis exist, where the chronic form is usually a low-grade disease without any clinical symptoms, and the acute form is more symptomatic.
Symptoms and Types
Cats are more commonly seen with clinical symptoms as compared to dogs. Such symptoms include:
- Weight loss
- Respiratory problems, like shortness of breath
- Uncoordinated gait
- Muscular weakness
- Partial or complete paralysis
- Abdominal Pain
- Loss of appetite
- Inflammation of tonsils (tonsillitis)
- Inflammation of retina (retinitis)
- Inflammation of middle part of the eye including iris (uveitis)
- Inflammation of the cornea (keratitis)
Symptoms are most severe in kittens infected while in the womb. These kittens may be stillborn or die before weaning. Those which survive may show show lack of appetite, fever, dyspnea, and jaundice.
Cats become infected through contact with the T. gondii parasite, which may be acquired from rooting in infected soil or from ingesting cat feces.
You will need to give a detailed history of your cat's health, onset and nature of symptoms, and possible incidents that might have precipitated this condition, such as contact with other cats. Your veterinarian will perform a thorough physical exam to evaluate your cat's body systems and to evaluate the overall health of your cat. Routine laboratory tests -- such as a complete blood count, biochemistry profile, and urinalysis -- are also used to confirm infection.
For example, cats with toxoplasmosis may show an abnormally low number of white blood cells (leukopenia), low neutrophils (neutropenia), and low lymphocytes (lymphopenia) in the complete blood count.
Conversely, during recovery, the complete blood count may reveal an increased number of white blood cells, an indication of the increased activity of the infection fighting white blood cells.
The biochemistry profile usually reveals abnormally high levels liver enzymes ALT (alanine aminotransferase ) and AST (aspartate aminotransferase). Moreover, the level of albumin (the protein normally present in the blood) is also found to be at decreased levels in some cats with toxoplasmosis; a medical condition known as hypoalbuminemia. In about 25 percent cats with toxoplasmosis, jaundice is seen with disturbed liver enzymes ALT and AST. The urinalysis may reveal abnormally high level of proteins and bilirubin in the urine sample. Fecal samples may also reveal important information, as infected cats frequently shed parasite eggs in their feces. If you have a sample of your cat's feces that you can take with your to your veterinarian, it may help to make the diagnosis and treatment move along faster.
Serological tests are the most reliable tests for making a definitive diagnosis. By measuring the levels of toxoplasma antigens in the body, your veterinarian can determine the type of infection, and whether it is active, dormant, recent (acute), or long term (chronic). Your veterinarian may repeat these tests three weeks after the initial testing as part of a follow-up exam.
Serological tests will also help in determining the levels of antibodies IgM and IgG. Antibodies are proteins that are normally present in the body or produced in response to an antigen (in this case toxoplasma) for the purpose of neutralizing the antigen. Determining the IgM levels helps in diagnosis of active toxoplasmosis, as these antibodies increase in number within one week of infection and may remain elevated for three months. The IgG antibodies increase within two to four weeks after infection and may remain elevated for a whole year to follow. Determination of antigen and antibody levels will help your veterinarian make the confirmatory diagnosis. The polymerase chain reaction test is a reliable test for verifying the presence of Toxoplasma gondii in samples.
Diagnostic imaging may also be called for, including a thoracic (chest) X-ray, which may show changes in the lung tissue, showing infection and marks of complications that are related to infection. Your veterinarian may also take a sample of lung fluid to determine the presence of the T. gondii organism, especially in cats with lung involvement. More advanced diagnostic testing includes taking a collection of cerebrospinal fluid (CSF). Laboratory testing of CSF may reveal an abnormally high number of white blood cells (WBCs) and protein concentrations in patients with infection that has reached the central nervous system.