Doxycycline

PetMD Editorial
Nov 07, 2012
2 min read

Drug Details

  • Drug Name: Doxycycline
  • Common Name: Vibramycin®, Doxychel®, Doxy Caps®, Bio-tab®, Monodox®, Doryx®, Doxirobe®
  • Drug Type: Broad spectrum antibiotic
  • Used For: Bacterial infections
  • Species: Dogs, Cats
  • Administered: Tablets, Oral liquid
  • How Dispensed: Prescription only
  • FDA Approved: Yes

General Description

Doxycycline is a broad spectrum antibiotic that is a member of the tetracycline family. It is used to fight bacterial infections in dogs and cats. Doxycycline is used to treat many different bacterial infections including, leptospirosis, toxoplasmosis, mycoplasma, psittacosis, and tick borne diseases including Lyme disease, ehrlichiosis, and Rocky Mountain spotted fever.

How It Works

Doxycycline binds to specific cell parts (ribosomes) of the bacteria and inhibit the protein synthesis, thus not allowing the bacteria to grow and divide. The process of shutting the protein synthesis down is not rapid. For this reason treatments using Doxycycline are generally termed as a long term treatment. It takes some time after the process is shut down until NSAIDs work by reducing the enzyme COX-2. COX-2. these enzymes are involved in the formation of prostaglandins which cause swelling and inflammation. Reduction of these factors reduce the pain and inflammation your pet experiences.

Storage Information

Store in a tightly sealed container at room temperature. Refrigerate unreconstituted oral gel. Once reconstituted, refrigerate and use within three days.

Missed Dose?

If you miss a dose, give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

Side Effects and Drug Reactions

Doxycycline may result in these side effects:

  • Nausea
  • Vomiting
  • Swallowing difficulties


If Doxycycline makes your pet nauseous, try administering it with food. If it makes your pet have breathing or swallowing problems, follow tablet with a small amount of water.

Doxycycline may react with these drugs:

  • Antacids
  • Anticoagulants
  • Bactericidals
  • Barbiturates
  • Cathartics
  • Gastro-intestinal protectants
  • Aminophylline
  • Digoxin
  • Insulin
  • Iron dextran
  • Kaolin/Pectin
  • Methoxyflurane
  • Sodium bicarbonate
  • Theophylline

USE CAUTION WHEN ADMINISTERING THIS DRUG TO YOUNG PETS, PREGNANT OR LACTATING PETS, OR PETS WITH SEVERE LIVER DISEASE

DO NOT BRUSH TEETH WITHIN 2 WEEKS OF ADMINISTRATION OF DOXIROBE