Urolithiasis is a medical condition referring to the presence of uroliths -- stones, crystals or calculi -- in the kidneys, bladder or anywhere in the urinary tract. Rats with this condition suffer from secondary bacterial infections and pain due to the rubbing of the uroliths against the urinary tract. Male rats are more prone to urolithiasis because of their longer urethras.
Symptoms and Types
Uroliths are rough in nature, causing the rat's urethra, urinary bladder or kidneys to become inflamed. Kidneys can also become inflamed due to secondary bacterial infections. Rats suffering from this condition will lick or bite the urinary area. And while some are unable to urinate or at least urinate properly, others frequently urinate but only in small amounts, leaving the fur around the perineum damp. In severe cases, urolithiasis may lead to renal failure. Some other symptoms include:
- Painful and difficult urination
- Cloudy urine
- Bloody urine
- Foul-smelling urine
- Loss of appetite
- Abdominal pain
The consistency of uroliths depends on the types of minerals or solutions in the formations. For example, urolithiasis struvite stones consist of magnesium ammonium phosphate and causes the rat's urine to become highly alkaline, and urolithiasis cystine stones consist of calcium oxalate, causing the urine to become highly acidic. Meanwhile, ammonium acid urates and silicate stones cause the urine pH to become either neutral or acidic.
There are several known risk factors for urolithiasis including diseases and conditions such as leukemia, diabetes, paralysis and diverticula (balloon-like growths on the bladder). Some other causes include:
- Abnormally high levels of calcium in the blood
- Improper diet
- Parasitic infections in the bladder (e.g., threadworm)
- Bacterial infections
Heredity can also cause urolithiasis in rabbits.
Other than observing the rat's clinical symptoms, the veterinarian will conduct X-rays and urine examinations to confirm the diagnosis. Culture and sensitivity tests may be required if secondary bacterial infections are present.