Rabies is an inflammatory infection that specifically affects the gray matter of the brain and central nervous system. Once the virus enters the cat's body, it replicates in the cells of the muscles and then spreads to the closest nerve fibers, including all peripheral, sensory, and motor nerves, traveling from there to the CNS via fluid within the nerves. Fortunately there is a vaccination against the rabies virus. Depending on the type of vaccine your veterinarian uses, it can be given at either 8 or 12 weeks of age. For the recombinant vaccines, boosters are recommended annually.