Erosive, Immune-Mediated Polyarthritis in Cats
Erosive, immune-mediated polyarthritis is an immune-mediated inflammatory disease of the joints, in which the cartilage of the cat's joint (articular cartilage) is eroded away.
Leukocyte cells, leukocyte enzymes (catalyzing reactions), cell-mediated immunity, immune complexes (an antibody bound to its triggering antigen), and autoallergic reactions are all directed against cartilage components. This leads to an inflammatory response by the tissue surrounding the cartilage, and protein activation (complement) in response to the immunity displaying cells.
Destructive enzymes, which are released from inflammatory cells, damage the articular cartilage, synoviocytes (cells which produce a lubricating fluid, called synovia, for the joints), and chondrocytes (cartilage cells), leading to erosive changes in the joints.
The condition or disease described in this medical article can affect both dogs and cats. If you would like to learn more about how this disease affects dogs, please visit this page in the PetMD health library.
Symptoms and Types
Symptoms for cats are often cyclic, coming and going at random intervals. These symptoms include:
- Lameness (ocassionally shifting-leg lameness)
- Stiffness in walk
- Decreased range of motion
- Cracking of the joints
- Joint swelling and pain in one or more joints
- Joint instability, subluxation, and luxation
The typical onset of immune-mediated erosive polyarthritis in cats is from one to five years of age and the most common type of the disease is feline chronic progressive polyarthritis (FCCP).
The suspected causes for this form of joint cartillage erosion are T lymphocyte effector cells that carry out the attack response, and an abnormal antigenic response to the host antibody. That is, an immune response to a substance that stimulates production of antibodies, an antigen, which acts as a “trigger.” Other known causes include:
- Feline leukemia virus (FeLV) and feline syncytium-forming virus (FSFV) -- both of which have been linked to cats with feline chronic progressive polyarthritis (FCPP)
You will need to give your veterinarian a thorough history of your cat's health leading up to the onset of symptoms. Your veterinarian will perform a thorough physical exam on your cat, taking note of signs of pain, decreased range of motion, and any lameness.
A complete blood profile will be conducted, including a chemical blood profile, a complete blood count, a urinalysis, and an electrolyte panel. Joint fluid aspirate will be taken for lab analysis, and submitted for bacterial culture and sensitivity. A biopsy of synovial tissue will also help to make a definitive diagnosis.
X-ray images can also be used as a diagnostic tool. If an erosive, immune-mediated polyarthritis condition is present, it will be visible on the radiograph image.