Q. Hematuria in 5 y/o golden retriever with neg. XR, lab work, ultrasound, urine cultures. 75-100 RBC's per HPF. Differential diagnosis?

A. Thanks for your question.

In my opinion, considering the results of the tests done so far, differential in this case are:

- Idiopathic cystitis

- Drug related hematuria (from medications if she is on any)

- Trauma to bladder, urethers, urethra.

- Uroliths and crystals (even with negative previous investigations done)

-Issues involving the genitalia:

Heat cycle, or estrus

Neoplasia (vagina, uterus)

Cancer or tumors

Infectious disease

Inflammatory disease

Symptomatic treatment based on antibiotics and non steroidal antinflammatories may be attempted.

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A. It is impossible to give a diagnosis without examination or symptoms in addition to the hematuria. Lyme disease, kidney issues and chronic inflammation as well as trauma may all cause hematuria and may not show up on blood work or X-ray readily. Further blood work , tests such as ultrasound or referral to a specialist may be needed to determine the issue.

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