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What is a Titer Test, and is it Right for Your Pet?

by David F. Kramer

The last 20 years has seen a growing anti-vaccination movement, which ostensibly began with a since debunked study published in 1998 that linked a common childhood vaccination with a little understood brain disorder. It led, and continues to lead, many parents to opt out of core vaccinations for their children. Admittedly, much of the furor has been internet and media driven, but it has made many people take a second look at the issue of vaccinating as a whole. Members of the veterinary community report that they are also seeing a decrease in vaccination.

To address this growing public concern, a medical procedure called the titer test can be used to determine the need for vaccination.

What is a Titer Test?

A titer test is a blood screen that measures the body’s level of immune system proteins—what we call antibodies. Antibodies are produced in response to some kind of antigen, or stimulus. Some typical stimuli that can produce this response include infection with bacteria, viruses, and parasites.

When a pet (or person) is vaccinated, the body creates an immune response, in part, by producing antibodies to fight the assailant. Thereafter, the immune system is able to quickly recognize the invader and launch an effective defense against the attacking microorganism.

The reason vaccines rarely produce illness is because vaccines are made from tiny, replicated parts of the virus, bacteria, or from germs that are either already dead or have been very much weakened. This helps the body to build immunity without making the recipient sick. To be sure, full immunity is not 100% certain for all vaccinated pets and some individuals can have allergic or other adverse reaction to vaccines, but on the whole, the benefits of appropriate vaccination far outweigh any risks.

According to Dr. Patrick Mahaney, a Los Angeles, CA, based holistic vet, pets and people have two types of immunity: innate and acquired. We are born with innate immunity that we get from developing within our mother’s body. Kittens, puppies, people, and other mammals who are nursing will continue to develop immunity during that process. Acquired immunity comes both from being environmentally exposed to infectious organisms, or purposefully through vaccination.

Titer screenings in pets can play a role in the decision of when to vaccinate and which vaccines to give. As is the case with human vaccinations, the veterinary community is somewhat divided on the issue.

Dr. Adam Denish, of Rhawnhurst Animal Hospital in Pennsylvania, has some special concerns when it comes to the issue of vaccination and titer tests “I own two animal hospitals and a boarding kennel, so we do recommend vaccinations based on the risk for that animal. It is my opinion, and the opinion of other doctors, that vaccination is the right way to go for most of these animals.”

“However, over the last 10 years there has been a movement by the anti-vaccinators, as well as by people who believe that vaccinations last longer than the once a year or once every three year program,” says Denish. “So sometimes owners ask for a titer level, and if they’re acceptable for both distemper and parvo, then that dog gets an extra year before we test it again. While most vaccines do last longer than the manufacturer recommends for a booster, no one knows for sure.”

State Laws and Core Vaccinations

“What I suggest for puppies and kittens is to vaccinate according to state law, which is typically just rabies,” says Mahaney. “Then I’ll also vaccinate for what are considered to be core diseases—those which are most likely to cause your pet to get severely sick, such as canine distemper virus (CDV) and canine parvovirus (CPV).” Mahaney says he also sometimes recommends vaccinating against “other agents which are not considered to be fatal, and are therefore considered ‘non-core,’ such as coronavirus, adenovirus, and Bordetella (aka kennel cough).”
 

Veterinarians look at a variety of factors when it comes to determining if and when an adult animal needs a booster including the individuals lifestyle and risk factors, disease prevalence in the area, and the manufacturer’s instructions. For those who are concerned about over-vaccinating their pets, a titer test can provide evidence as to whether an animal is producing antibodies against a disease, or whether further inoculation is necessary.

On the negative side, Denish says there is no way to predict antibody levels three or six months down the line. Resistance levels can change due to any number of factors, including stress, disease, and medication, so there is a concern that these levels might not be consistent over time.

As the owner of a boarding kennel, Denish prefers more proof of an animal’s resistance before risking exposure to other animals in his care. There is no titer test for Bordetella, for example, so he prefers to play it safe rather than risk a kennel cough infection spreading throughout a group of boarded animals, as well for the protection of those dogs the infected animals might contact.

How Money Influences Vaccines

Some veterinarians express concern that the companies that make vaccines are more concerned with moving their products, and in the process, pressure veterinarians to push vaccines even when they are not needed. And since money can be made on vaccines, many vets go along with it.

“Veterinarians commonly make money off of vaccines because the cost is very minimal, so they mark up the cost of providing a vaccination,” says Mahaney.

Some markup is to be expected of course, since administering the injections takes time and labor on behalf of the veterinarian or veterinary technician. For vets who are recommending, and providing, three or four vaccines in one session, a small profit can be made. “Such is the case with mobile vaccine clinics,” says Mahaney, “it’s a method of generating practice income without having high overhead.”

Annual shots are not always necessary, adds Mahaney. “If you have properly immunized during kittenhood and puppyhood, very often the immunity for the agents carries on for longer than the recommended interval to provide a booster shot—sometimes months to years.”


According to Denish, a distemper-parvo battery titer costs about $76, while the vaccine is about $24. Because there is always the chance that an already paid for titer will show that a vaccination is required anyway, many owners would just as soon opt solely for the vaccination, if only for financial reasons.

Adverse Reactions to Vaccines

The main concern surrounding vaccination, then, is the potential for a vaccine associated adverse event (VAAE), which is when a pet has a bad reaction to a vaccination, whether serious or mild. According to Mahaney, while reactions are the exception, these events are more likely to occur when pets are already sick with immune mediated diseases or cancers (e.g., lymphoma, multiple myeloma, leukemia, or tumors), or are taking drugs that suppress the immune system, such as with steroids or chemotherapy. Additionally, some smaller breeds, such as Chihuahuas, pugs, and Yorkshire terriers, are more predisposed to brain swelling and other conditions associated with VAAEs.  

Adverse reactions to vaccines can occur within minutes or hours after a dose is given, or can manifest over a longer period of time. Symptoms of an allergic reaction to a vaccine can include hives, vomiting, diarrhea, low blood pressure, decreased appetite, lethargy, swelling, collapse, and can sometimes result in coma or death.

Are Vaccines Overused?

As opposed to having conflicted feelings for or against vaccinations or titer screenings, Mahaney stresses that there are far more important health issues to tackle when you take your pet to the veterinarian. It is a misconception to assume that a vaccinated pet is completely safe from getting the disease. 

“I do believe that vaccinations are probably overused,” says Denish, “but the purpose of coming to a veterinarian on a yearly basis is to make sure that your animal is healthy. Vaccinations, while important, are secondary to other health issues, such as heartworm, Lyme disease, and fecal testing [for parasites].”

What compounds this, Denish says, is that when vaccine manufacturers improve their products to last longer, pet owners can sometime use this as a reason to visit their vet less often. Sometimes, owners will only bring their pets to a veterinarian when a groomer or kennel requires documentation of vaccination before offering their services.

On the other hand, “Fear that their pets will acquire a disease prevented by vaccines motivates many owners to pursue vaccination despite the potential for a pet to still have immunity from his previous vaccinations,” says Mahaney.

“Additionally, many owners don’t consider the overall state of health of the pet, and the diseases that are actually present in the body, like periodontal disease and obesity, [which] are often not fully addressed during routine appointments for vaccinations.”

So, while the jury may still be out on the issue of vaccination versus titer testing, this conflict is no excuse not to take your pet to his or her veterinarian for regular examinations. Regular checkups will do far more to ensure the continual health of your pets than relying on vaccination alone.

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