A. I'd agree that panosteitis is unlikely in a 2 year old dog, however it is possible. Luckily it's pretty easy to diagnose. The pain is extremely obvious when the long bones are palpated from middle to almost end. Classically, the dog will be standing as you press along the bone, and then you'll get to the spot with the lesion, and the dog will yelp in pain, or try to bite you. So I think if your dog had pano, you'd know it, and your vet would have figured it out.
If your dog has been through rigorous diagnostics like x-rays and blood work and no cause has been found, I think (unfortunately) it's time to see a specialist. I'm really suspicious of a spinal problem, as they can be really difficult to find with routine examination and x-rays. A veterinary neurologist can perform a full neuro exam to look for deficits, and then if findings point to a possible spinal issue suggest imaging, possibly an MRI. In a dog as young as yours if nothing obvious has been found I suspect it's in the spinal area. GSDs are predisposed to lumbosacral stenosis, so that's where I'd start looking. Good luck.
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