A. Forty pound weight loss is severe. I would recommend that you make an appointment with your veterinarian as soon as possible for an exam and the appropriate diagnostic tests. They will likely recommend bloodwork and radiographs, or X-rays, to start with.
Depending on the results, additional diagnostic tools may be recommended, such as ultrasound. The possibilities are numerous including malabsorption problem, diseases of the small or large intestine, kidney disease, liver disease, diabetes and cancer. Your veterinarian can examine her and determine what steps to take next.
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