A. These interdigital cysts, or more accurately furuncles, are typically caused by bacterial infection. The most effective treatment is a combination of systemic and topical antibiotic therapy. See your vet for an exam and diagnostics to rule out auto immune conditions, allergies or sensitivities and foreign body. Place an e-collar on your dog to prevent excessive licking. You can soak the affected paw in an Epsom salt solution to provide some relief.
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